血清脂联素、高敏C反应蛋白和白细胞介素-6对急性脑梗死患者的影响研究

盘毓旻; 文治成; 贺传沙

doi:10.13201/j.issn.1009-5918.2016.11.015

血清脂联素、高敏C反应蛋白和白细胞介素-6对急性脑梗死患者的影响研究

- 重庆市长寿区人民医院神经内科(重庆, 401220)

详细信息

通讯作者: 盘毓旻,E-mail:635644312@qq.com

中图分类号: R743.3

收稿日期: 2016-08-31

Study of association of serum adiponectin、hs-CRP and IL-6 with acute cerebral infarction

- Department of Neurology, People's Hospital of Changshou Chongqing, Chongqing, Changshou 401220, China

More Information

Corresponding author: PAN Yumin, E-mail: 635644312@qq.com

Received Date: 31 August 2016

摘要

摘要: 目的:初步探讨血清脂联素(ADPN)、高敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)在急性脑梗死(acute cerebral infarction,ACI)中的动态变化,并测定其与ACI病情严重程度之间的关系。方法:随机选取于我院就诊的65例ACI住院患者(ACI组)及30例健康成人(对照组),均于发病后24 h内入院,分别在入院时、第1周末、第2个月末抽取空腹静脉血,采取免疫增强比浊法测定hs-CRP,采取酶联免疫吸附剂测定(ELISA)法动态检测血清ADPN、IL-6的水平,采取改良爱丁堡-斯堪的纳维亚评分(MESSS)评价ACI的严重程度,采用方差分析与Pearson相关分析,行SPSS 18.0统计软件包处理结果。结果:ACI组hs-CRP和IL-6水平在发病后入院时、第1周末、第2个月末均高于对照组(P<0.05),ADPN在入院时、第1周末明显降低(P<0.01),而第2个月末呈升高趋势,但与对照组比较差异无统计学意义。MESSS在ACI入院时、第1周末、第2个月末时分别为(17.8±10.4)、(14.2±10.3)和(10.7±9.9)。MESSS与hs-CRP水平有统计学意义(r=0.228,P=0.015),但与IL-6、ADPN水平之间差异无统计学意义(r=-0.058,P=0.659;r=0.007,P=0.213)。结论:血清hs-CRP、IL-6水平在ACI发病后升高,ADPN部分时间段降低,说明炎性因子可能参与了ACI发生、发展的过程。
- 脂联素 /
- 高敏C反应蛋白 /
- 白细胞介素-6 /
- 急性脑梗死
Abstract: Objective:To investigate the dynamic change of Serum adiponectin (ADPN),high sensitivity c-reactive protein (hs-CRP) and interleukin-6(IL-6) during acute cerebral infarction (ACI),and to analyze the relationship between these factors and the severity of ACI.Method:Take a completely random selection of our 65 ACI patients in the hospital,and 30 cases of healthy adults outpatient as control group,both within 24 hours after the onset of hospital.Immune enhancement turbidimetric method to determine the hs-CRP,enzyme-linked immune sorbent assay (ELISA) method to measure the levels of serum ADPN,IL-6 dynamic in the onset of hospital,the first weekend,and end of two months,evaluate the severity of ACI with the improvement of Edinburgh-Scandinavianscore (MESSS),analysis to process resultsusing variance analysis and Pearson correlation (SPSS 18.0 statistical software package).Result:Level of hs-CRP and IL-6 in ACI group in the admission,first weekend,end of 2 months were higher than control group (P<0.05),ADPN was significantly lower in the onset and the first weekend (P<0.01),while the rising trend in the end of 2 months,but there was no statistically significant difference compared with the control group.Average of MESSS in ACI in admission,first weekend,the end of 2 months respectively was (17.8±10.4),(14.2±10.3),(10.7±9.9).Levels of MESSS and hs-CRP have significant difference (P=0.015),while the levels of serum IL-6,ADPN was not.Conclusion:Serum hs-CRP,IL-6 levels rised after the onset of ACI,ADPN was reducedin part time,shows that inflammation factors may be involved in Acute Cerebral Infarction.
- adiponectin /
- hs-CRP /
- interleukin-6 /
- acute cerebral infarction

HTML全文

参考文献(16)

[1]	黄家俊,杜林,汪永强,等.脑梗死患者颈动脉斑块与炎性因子的相关性研究[J].中国实用神经疾病杂志,2016,19(14):6-8.
[2]	Wang H,Peng D Q.New insights into the mechanism of low high-density lipoprotein cholesterol in obesity[J].Lipids Health Dis,2011,10(5):176.
[3]	Tanaka R,Ueno Y,Miyamoto N,et al.Impact of diabetes and prediabetes on the short-term prognosis in patients with acute ischemic stroke[J].J Neurol Sci,2013,332(1-2):45-50.
[4]	Chen M P,Tsai J C,Chung F M,et al.Hypoadiponectinemia is associated with ischemic cerebrovascular disease[J].Arterioscler Thromb Vasc Biol,2005,25(4):821-826.
[5]	Gardener H,Sjoberg C,Crisby M,et al.Adiponectin and carotid intima-media thickness in the northern Manhattan study[J].Stroke,2012,43(4):1123-1125.
[6]	李猛,宣之东,于瑞敏,等.脑梗死患者血清脂联素、瘦素、CRP、IL-6与颈动脉内中膜厚度相关性研究[J].脑与神经疾病杂志,2013,24(2):118-122.
[7]	Hui X,Lam K S,Vanhoutte P M,et al.Adiponectin and cardiovascular health:an update[J].Br J Pharmacol,2012,165(3):574.
[8]	梅炳银.脑梗死患者脂联素、瘦素及炎性因子水平与颈动脉内中膜厚度的相关性研究[J].中国实用神经疾病杂志,2016,19(14):34-36.
[9]	Arregui M,Buijsse B,Fritsche A,et al.Adiponectin and risk of stroke:prospective study and meta-analysis[J].Stroke,2014,45(1):10-17.
[10]	Gao M,Ding D,Huang J,et al.Association of genetic variants in the adiponectin gene with metabolic syndrome:a case control study and systematic meta-analysis in the Chinese population[J].PLoS One,2013,8(4):e58412.
[11]	周厚杰,刘宏斌,郭强,等.脑出血患者高敏C反应蛋白的变化分析[J].中国实用神经疾病杂志,2015,18(13):22-23.
[12]	杨丽萍,张晓炜,张国华,等.急性脑梗死患者血清YKL-40、hs-CRP水平与颈动脉粥样硬化斑块的相关性研究[J].中风与神经疾病杂志,2013,30(4):306-308.
[13]	Zhou P,Li Y Q,Li W D,et al.Changes in serum high mobility group box-1protein and high-sensitivity Creactive protein in patients with acute cerebral infarction and their clinical significance[J].Zhongguo Wei Zhong Bing Jijiu Yi Xue,2012,24(5):265-268.
[14]	Anogeianaki A,Angelucci D,Cianchetti E,et al.Atherosclerosis:a classic inflammatory disease[J].Int J Immunopathol Pharmacol,2011,11(4):817-825.
[15]	Shen D,Xing S,Chen C.Adiponectin gene polymorphisms contributes to ischemic stroke risk:A meta-analysis[J].J Renin Angiotensin Aldosterone Syst,2015,16(1):178-184.
[16]	Jauch E C,Saver J L,Adams H P Jr,et al.Guidelines for the early management of patients with acute ischemic stroke:a guideline for healthcare professionals from the American Heart Association/American Stroke Association[J].Stroke,2013,44(3):870-947.