Abstract: Objective:To observe the curative effect of somatostatin combined with Salvia miltiorrhiza in the treatment of severe acute pancreatitis and its effect on the level of serum factors.Method:78 patients of severe acute pancreatitis were stratified and randomly divided into 2 groups,including 39 cases using somatostatin as the control group.The other 39 cases were treated with somatostatin and Salvia miltiorrhiza as the study group.The recovery time,serum factor level,clinical efficacy,adverse reaction and mortality were observed and compared between the two groups.Result:The recovery time of relevant clinical indexes (stomach pain,abdominal distension,exhaust,borborygmus,serum amylase and WBC) was shorter than the control group,the difference was statistically significant (P<0.05).The expression level of TNF-α,IL-6,IL-8,alpha PAF in both groups of patients significantly decreased after treatment,but the study group decreased more significantly than control group (P<0.05).The effective rate of treatment group was 81.1% (30/37),while in the study group,the effective rate of treatment was 91.9% (34/37),with significant statistical significance (P<0.05).The adverse reaction rate in the control group was 13.5% and the death rate was 5.4%,while in the study group the adverse reaction rate were 16.2% and 2.7%,the two groups had no statistically significant difference in mortality and adverse reaction rate.Conclusion:Somatostatin combined with Danshen injection in the treatment of severe acute pancreatitis has good curative effect,which can significantly shorten the recovery time of the relevant clinical indexes,reduce serum expression levels,and improve the prognosis of patients,which is worthy of clinical application.