急性一氧化碳中毒患者低频振幅算法功能磁共振研究

陈俊; 马爱闻; 楚涛; 范璐; 徐继扬

doi:10.13201/j.issn.1009-5918.2015.12.014

急性一氧化碳中毒患者低频振幅算法功能磁共振研究

- 苏北人民医院扬州大学临床医学院急诊医学科(江苏扬州, 225001)

详细信息

通讯作者: 徐继扬,E-mail:yzjz120@163.com

中图分类号: R595.1

收稿日期: 2015-08-27

Application of amplitude of low-frequency fluctuation to acute carbon monoxide poisoning: a resting state fMRI study

- Department of Emergency Medicine, Subei People's Hospital & Clinical Medical School of Yangzhou University, Yangzhou 225001, China

More Information

Corresponding author: XU Jiyang, E-mail: yzjz120@163.com

Received Date: 27 August 2015

摘要

摘要: 目的：采用低频振幅（ALFF）方法评价急性一氧化碳中毒（ACMP）患者静息状态下脑功能活动。方法：运用功能磁共振技术（fMRI）观察ACMP患者脑血氧水平依赖信号（BOLD）的ALFF改变；采集12例ACMP患者及14例对照组的BOLD数据，运用ALFF算法分析获得每个被试者的统计图，用两独立样本t检验，以P<0.05，t>2.05为阈值，显示ACMP组相对于对照组的ALFF增高和减弱的区域。结果：与对照组比较，ACMP组在左侧舌回（-12，-90，-3）及右侧颞下回（57，-66，-15）ALFF值明显增高。结论：ACMP患者静息状态下表现出异常脑功能活动，这些异常活动可能与迟发型脑病（DE）的产生相关。
- 急性一氧化碳中毒 /
- 静息态功能性磁共振 /
- 低频振荡幅度
Abstract: Objective: To evaluate brain activity in resting-state of acute carbon monoxide poisoning (ACMP) with amplitude of low-frequency fluctuation (ALFF).Method: The amplitude of low-frequency fluctuation of the blood oxygenation level dependent activation of the resting state brain was calculated in 14 healthy controls (HC) and 12 patients with ACMP.The brain regions showing increased and decreased ALFF in ACMP patients were demonstrated by comparing to HC with 2-sample t-test with threshold of P<0.05.Result: Compared with HC,the ACMP patients showed increased activity in left lingual gyrus(-12-90-3) and right inferior temporal gyrus(57-66-15).Conclusion: ACMP shows abnormal brain functional organization in resting state,which may play an important role in the nenrophysiological mechanisms of delayed encephalopathy(DE) after ACMP.
- acute carbon monoxide poisoning /
- resting-state functional magnetic resonance imaging /
- amplitude of low-frequency fluctuation

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