心型脂肪酸结合蛋白在早期急性心肌梗死诊断中的价值研究

李蓉

doi:10.13201/j.issn.1009-5918.2015.12.011

心型脂肪酸结合蛋白在早期急性心肌梗死诊断中的价值研究

李蓉^,

- 宝鸡市人民医院重症医学科(陕西宝鸡, 721000)

详细信息

通讯作者: 李蓉,E-mail:lirong197012@sina.com

中图分类号: R542.2

收稿日期: 2015-08-04

Value of H-FABP in early diagnosis of acute myocardial infarction

LI Rong^,

- Department of Critical Care Medicine, Baoji City People's Hospital, Baoji 721000, China

More Information

Corresponding author: LI Rong, E-mail: lirong197012@sina.com

Received Date: 04 August 2015

摘要

摘要: 目的：分析心型脂肪酸结合蛋白（H-FABP）在早期急性心肌梗死（AMI）诊断中的价值。方法：选取2013-06-2015-06我院收治的发作时间<3 h急性胸痛患者84例，将其分为AMI组和非AMI组，每组各42例。比较2组患者H-FABP、肌钙蛋白I（cTnI）、肌酸激酶同工酶（CK-MB）和肌红蛋白（Mb）水平，分析各心肌损伤标志物对于AMI诊断的灵敏度和特异度。结果：AMI组0~3 h、>3~6 h的H-FABP、cTnI和Mb显著高于非AMI组，>3~6 h的CK-MB显著高于非AMI组（P<0.01）；H-FABP在0~3 h诊断AMI的灵敏度和特异度分别为95.24%和100%，显著高于cTnI、CK-MB和Mb（P<0.05）；H-FABP在>3~6 h诊断AMI的灵敏度和特异度均为100%，显著高于CK-MB和Mb（P<0.05）。H-FABP在0~3 h、>3~6 h对于AMI的诊断准确性高于cTnI、CK-MB和Mb。结论：H-FABP诊断早期AMI优于cTnI、CK-MB和Mb等心肌标志物。
- 心型脂肪酸结合蛋白 /
- 早期 /
- 急性心肌梗死
Abstract: Objective: To analyze the diagnostic value of heart-type fatty acid binding protein (H-FABP) in early acute myocardial infarction (AMI).Method: Eighty-four cases of patients with acute chest pain and onset time <3 h in critical care unit of our hospital from June 2013 to June 2015 were selected,and were divided into AMI group (n=42) and non-AMI group (n=42).H-FABP,cTnI,CK-MB and Mb level of two groups were compared.Each cardiac injury markers for AMI diagnostic sensitivity and specificity were analized.Result: H-FABP,cTnI and Mb of 0~3 h,>3~6 h in the AMI group were significantly higher than that of the non-AMI group and gradually increased.CK-MB of >3~6 h in the AMI Group was significantly higher than that of the non-AMI group (P<0.01).The sensitivity and specificity of H-FABP to the diagnosis of AMI 0~3 h were 95.24% and 100%,which were significantly higher than that of cTnI,CK-MB and Mb (P<0.05).The sensitivity and specificity of H-FABP to the diagnosis of AMI >3~6 h were both 100%,which were significantly higher than that of CK-MB and Mb (P<0.05).H-FABP of 0~3 h,>3~6 h had higher diagnostic accuracy than AMI,cTnI,CK-MB and Mb.Conclusion: To the diagnosis of early AMI,H-FABP is better than cTnI,CK-MB and Mb and other cardiac markers.
- heart-type fatty acid binding protein /
- early /
- acute myocardial infarction

HTML全文

参考文献(14)

[1]	古平,潘波,牟海刚.急诊PCI与择期PCI治疗急性心肌梗死的临床对比分析[J].现代仪器与医疗,2014,13(2):22-29.
[2]	车大胜.联合检测三项血清水平对急性心肌梗死的诊断意义[J].检验医学与临床,2014,9(15):2137-2138.
[3]	朱应才.心肌损伤标志物联合检测在早期诊断心肌梗死中的应用[J].心血管病防治知识月刊,2013,21(17):2214-2215.
[4]	高东美,徐伟,刘宇红.H-FABP在AMI早期诊断与治疗中的意义[J].中国保健营养旬刊,2014,24(1):88-98.
[5]	中华医学会心血管病学分会,中华心血管病杂志编委会,中国循环杂志编辑委员会.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志,2001,29(12):710-725.
[6]	中华医学会心血管病学分会,中华心血管病杂志编辑委员会.不稳定性心绞痛诊断和治疗建议[J].中华心血管病杂志,2000,28(6):409-412.
[7]	中华医学会心血管病学分会,中华心血管病杂志编辑委员会.慢性稳定性心绞痛诊断与治疗指南[J].中华心血管病杂志,2007,35(3):195-206.
[8]	Bhatia L C,Naik R H.Clinical profile of acute myocardial infarction in elderly patients[J].J Cardiovasc Dis Res,2013,4:107-111.[CM(80mm]
[9]	陈丽萍.急性心肌梗死心电图诊断的研究[J].实用心脑肺血管病杂志,2013,12(1):33-39.
[10]	Aldous S J.Cardiac biomarkers in acute myocardial infarction[J].Int J Cardiol,2013,164:284-294.
[11]	魏洁,蔡雪莲,徐杏安.心肌损伤标志物检测在早期急性心肌梗死诊断中的应用体会[J].现代诊断与治疗,2014,21(19):103-110.
[12]	夏杰.快速检测血浆心肌脂肪酸结合蛋白(H-FABP)在急性心肌梗死早期诊断中的临床价值[J].中国民康医学,2014,33(7):61-62.
[13]	刘甲兴,杨聪德,黄勉君.心型脂肪酸结合蛋白在急性心肌梗死6 h内的诊断价值临床军医杂志,2013,13(2):14-24.
[14]	谢明水,刘杨,刘国政.心肌脂肪酸结合蛋白在早期急性心肌梗死诊断中的临床价值[J].中国实验诊断学,2013,17(6):1019-1021.