Abstract: Objective: Compare Penehyclidine and Atropine in the treatment of pediatric curative effect and adverse reaction of organophosphorus pesticide poisoning.Method: Choose 29 cases of organophosphorus pesticide poisoning hospitalized children in our hospital PICU from March 2011 to June 2014 as treatment group,Using penehyclidine joint pralidoxime chloride;Choose organophosphorus pesticide poisoning of children from March 2008 to February 2008 as control group,Using Atropine joint pralidoxime chloride. Compare two groups of symptoms disappearing time,total hospitalization days,cholinesterase recovery time and children with severe poisoning cholinesterase recovery to 1/2 of the time and consciousness recovery time,and compare the two groups the incidence of adverse reactions in the process of treatment.Result: Compared with control group,treatment group symptoms disappear fast Treatment group showed less hospitalization daysand cholinesterase recovery time is short,especially children with severe poisoning cholinesterase recovery to 1/2 of the time and consciousness recovery time is short,the treatment group the incidence of adverse reactions was lower than those of control group.Conclusion: Penehyclidine better curative effect is better than atropine treatment of organophosphorus pesticide poisoning,with less adverse reaction.