急性脑卒中患者发生应激性溃疡并发症的危险因素分析

陈慧敏, 黄昌保, 狄佳, 等. 急性脑卒中患者发生应激性溃疡并发症的危险因素分析[J]. 临床急诊杂志, 2015, 16(3): 186-188. doi: 10.13201/j.issn.1009-5918.2015.03.007
引用本文: 陈慧敏, 黄昌保, 狄佳, 等. 急性脑卒中患者发生应激性溃疡并发症的危险因素分析[J]. 临床急诊杂志, 2015, 16(3): 186-188. doi: 10.13201/j.issn.1009-5918.2015.03.007
CHEN Huimin, HUANG Changbao, DI Jia, et al. Analysis of risk factors of complications in stress ulcer patients with acute cerebral stroke[J]. J Clin Emerg, 2015, 16(3): 186-188. doi: 10.13201/j.issn.1009-5918.2015.03.007
Citation: CHEN Huimin, HUANG Changbao, DI Jia, et al. Analysis of risk factors of complications in stress ulcer patients with acute cerebral stroke[J]. J Clin Emerg, 2015, 16(3): 186-188. doi: 10.13201/j.issn.1009-5918.2015.03.007

急性脑卒中患者发生应激性溃疡并发症的危险因素分析

  • 基金项目:

    中国人民解放军南京军区重大专项课题(No:12Z32)

详细信息
    通讯作者: 聂时南,E-mail:shn_nie@sina.com
  • 中图分类号: R743.3

Analysis of risk factors of complications in stress ulcer patients with acute cerebral stroke

More Information
  • 目的:探讨引起脑卒中患者发生应激性溃疡并发症的危险因素。方法:回顾性总结我科收治的脑卒中患者相关临床资料共计125例。结果:单因素分析结果显示,年龄(χ2=5.77)、脑卒中类型(χ2=18.90)、脑卒中严重程度(χ2=11.39)、神经功能缺损程度(χ2=9.45)和肠内营养情况(χ2=8.75)5个因素的应激性溃疡发生率具有统计学意义(P<0.05),Logistic回归分析结果显示,年龄(β=0.36)、脑卒中类型(β=0.45)、脑卒中严重程度(β=0.61)和神经功能缺损程度(β=0.70)是引起脑卒中患者发生应激性溃疡并发症的独立危险因素。结论:对于高龄、出血性脑卒中、重度脑卒中和GCS评分为3~8分的脑卒中患者,因其出现应激性溃疡并发症的危险性较大,应进行针对性的重点预防。
  • 加载中
  • [1]

    Abdel-Sater K A,Abdel-Daiem W M,Sayyed Bakheet M.The gender difference of selective serotonin reuptake inhibitor,fluoxetine in adult rats with stress-2induced gastric ulcer[J].Eur J Pharmacol,2012,688:42-48.

    [2]

    中华医学杂志编委会.应激性溃疡防治建议[J].现代实用医学,2003,15(4):260-261.

    [3]

    Alhazzani W,Alenezi F,Jaeschke R Z,et al.Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients:a systematic review and meta-analysis[J].Crit Care med,2013,41:693-705.

    [4]

    陈劲松,倪恒祥,王军,等.急性脑卒中合并应激性溃疡的危险因素分析[J].中国医科大学学报,2012,41(9):850.

    [5]

    中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志,2010,43(2):146-153.

    [6]

    Barkun A N,AdamV,Martel M,et al.Cost-effectiveness analysis:stress ulcer bleeding prophylaxis with proton pump inhibitors,H2 receptor antagonists[J].Value health,2013,16:14-22.

    [7]

    Karatepe O,Unal O,Ugurlucan M,et al.The impact of valvular oxidative stress on the development of venous stasis ulcer valvular oxidative stress and venous ulcers[J].Angiology,2010,61:283-288.

    [8]

    Issa I A,Soubra O,Nakkash H,et al.Variables associated with stress ulcer prophylaxis misuse:a retrospective analysis[J].Dig Dis Sci,2012,57:2633-2641.

    [9]

    Li Z M,Wang L X,Jiang L C,et al.Relationship between plasma cortisol levels and stress ulcer following acute and severe head injury[J].Med Princ Pract,2010,19:17-21.

    [10]

    Barkun A N,Bardou M,Martel M.Controversies in stress ulcer bleeding prophylaxis arise from differences in the quality of the evidence[J].Anaesth Intensive Care,2013,41:269-270.

    [11]

    Bez C,Perrottet N,Zingg T,et al.Stress ulcer prophylaxis in non-2critically ill patients:a prospective evaluation of current practice in a general surgery department[J].J Eval Clin Pract,2013,19:374-378.

    [12]

    Sumanen M P,Koskenvuo M J,Sillanmäki L H,et al.Peptic ulcer and childhood adversities experienced by working-aged people[J].World J Gastroenterol,2009,15:3405-3410.

    [13]

    Chang X R,Peng L,Yi S X,et al.Association of high expression in rat gastric mucosal heat shock protein 70 induced by moxibustion pretreatment with protection against stress injury[J].World J Gastroenterol,2007,13:4355-4359.

  • 加载中
计量
  • 文章访问数:  225
  • PDF下载数:  307
  • 施引文献:  0
出版历程
收稿日期:  2014-10-14

目录