H-FABP联合cTnI、CK、Mb、CK-Mb检测在ACS早期诊断中的价值

谢明水; 刘国政; 李玲; 敖晶晶; 刘杨; 张振建

doi:10.13201/j.issn.1009-5918.2013.12.006

H-FABP联合cTnI、CK、Mb、CK-Mb检测在ACS早期诊断中的价值

- 1. 随州市中心医院检验科(湖北随州, 441300);
- 2. 随州市中心医院心血管内科
基金项目:
湖北省卫生厅资助项目（No：2009JX4B69）

详细信息

通讯作者: 张振建,E-mail:cierra@126.com

中图分类号: R541.4

收稿日期: 2013-02-04

The value of heart-type fatty acid-binding protein and cTnI、 CK、Mb、CK-Mb in early ACS

- 1. Department of Clinical Laboratory, Suizhou Central Hospital, Suizhou, 441300, China;
- 2. Department of Cardiology, Suizhou Central Hospital

More Information

Corresponding author: ZHANG Zhen jian, E-mail: cierra@126.com

Received Date: 04 February 2013

摘要

摘要: 目的：探讨H-FABP与cTnI、CK、Mb、CK-Mb联合检测在急性冠脉综合征患者诊断中的临床价值。方法：采用ELISA法检测81例6h内胸痛发作患者的血清H-FABP水平，采用免疫荧光法测定这些患者血清中的cTnI、CK、Mb、CK-Mb，其中急性心肌梗死（AMI）30例、不稳定型心绞痛（UAP）26例、非心源性胸痛（NCCP）25例，同期选择27例健康体检者为对照组。应用Logistic回归模型绘制ROC曲线并计算曲线下面积（AUC）来评估H-FABP的诊断价值。结果：AMI组的H-FABP水平（73.35±56.73） μg/L最高，UAP组（13.50±5.64） μg/L次之（P<0.01）；NCCP组（4.07±3.27） μg/L与对照组（3.42±1.53） μg/L比较差异无统计学意义（P>0.05）。H-FABP诊断AMI敏感性（96.7%）明显优于cTnI诊断敏感性74.5%（P<0.05）；H-FABP与cTnI联合检测ROC曲线下面就更高达0.908。结论：H-FABP与cTnI联合检测可为急性冠脉综合征患者的诊断提供依据。
- 冠状动脉疾病 /
- 急性冠脉综合征 /
- 联合检测
Abstract: Objective: To investigate the clinic value of serum heart-type fatty acid-binding protein and cTnI、CK、Mb、CK-Mb on prognosis of patients with acute coronary syndrme.Method: The H-FABP level was measured within 6h after onset of chest pain in 81 patients by ELISA methods and cTnI、CK、Mb、CK-Mb by immunofluoresent assays.With 30 cases of acute myocardial infarction (AMI),26 cases of unstable angina pectoris (UAP),25 cases of non-cardiac chest pain (NCCP),at the same period 27 healthy volunteers were selected as the control group.H-FABP diagnosis value is evaluated by the area under the concentration-time curve of receiver operating characteristic rendered using Logistic regression model.Result: The H-FABP level (73.35±56.73) μg/L in AMI group was highest,and the H-FABP level (13.50±5.64) μg/L in UAP group was higher (P<0.01).There was no statistically significant between NCCP group (4.07±3.27) μg/L and the control group (3.42±1.53) μg/L.The sensitivity of H-FABP on diagnosis of AMI (96.7%) was significantly better than that of cTnI (80%)(P<0.05),comparison of specific between the two had no significant difference.The area under the concentration-time curve of receiver operating characteristic of H-FABP and cTnI is up to 0.908.Conclusion: The H-FABP and cTnI level could be diagnostic basis for acute coronary syndrme.
- heart-type fatty acid-binding protein /
- acute coronary syndrome /
- combined detection

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