高危型HPV/TCT检测在宫颈疾病筛查中的临床价值

李旺群

doi:10.13201/j.issn.1009-5918.2012.04.021

高危型HPV/TCT检测在宫颈疾病筛查中的临床价值

李旺群^,

- 武汉市蔡甸区妇幼保健院(武汉, 430100)

详细信息

通讯作者: 李旺群,E-mail:fkyslwq@163.com

中图分类号: R711.74

收稿日期: 2012-02-28

Clinic value of combination of high risk HPV test and ThinPrep liquid-based cytology in cervical screening

LI Wangqun^,

- Health Centre for Women and Children of Caidian, Wuhan, 430100, China

More Information

Corresponding author: LI Wangqun, E-mail: fkyslwq@163.com

Received Date: 28 February 2012

摘要

摘要: 目的：探讨高危型HPV（HR-HPV）检测联合宫颈液基细胞学（TCT）检查（HR-HPV/TCT）在宫颈疾病筛查中的临床价值。方法：回顾性分析2008-01-2011-01来我院就诊的自愿接受HR-HPV/TCT检测的患者2 140例。对TCT异常和TCT阴性而HR-HPV阳性的患者386例进行阴道镜加活检检查。结果：TCT异常者327例，ASCUS（意义不明宫颈不典型鳞状上皮细胞）196例，LSIL（低度宫颈上皮内病变）93例，HSIL（高度上皮内病变）38例。病理报告炎症156例，宫颈癌前病变（CIN） 160例（其中CIN Ⅱ级和Ⅲ级共60例），宫颈癌11例。HR-HPV检出率随宫颈病变级别的增高而上升（P<0.005）。TCT阴性而HR-HPV阳性的患者59例，病理报告炎症29例，CIN 27例（CIN Ⅱ级和Ⅲ级共12例），宫颈癌3例。结论：HR-HPV/TCT检测可有效检出宫颈CIN和宫颈癌，减少漏诊率。
- HR-HPV检测 /
- 宫颈不典型鳞状细胞 /
- 二代杂交捕获
Abstract: Objective: To discussion clinic value of high risk HPV (HR-HPV) testing combined with cervical liquid-based cytology (TCT) in cervical screening.Method: A total of 2 140 patients were tested for HR-HPV detection combined with TCT check from January 2008 to January 2011. Three hundred and eighty-six cases of abnormal and TCT TCT negative HR-HPV positive patients, colposcopy with biopsy examination.Result: TCT abnormal in 327 cases, 196 cases of ASCUS. (Of undetermined significance cervical atypical squamous cells), LSIL (low-grade cervical intraepithelial neoplasia) 93 cases of HSIL (high intra-epithelial lesions of 38 patients). Pathological report on inflammation in 156 cases, CIN160 cases (the which CIN Ⅱ level and Class Ⅲ 60 cases), 11 cases of cervical cancer. The HR-HPV detection rate increased with the increased level of cervical lesions (P<0.005). TCT negative HR-HPV-positive patients with 59 cases of inflammation of pathology reports of 29 cases, the CIN27 cases (12 cases CIN Ⅱ level and class Ⅲ), three cases of cervical cancer.Conclusion: HR-HPV/TCT detection can be effectively detected in cervical CIN and cervical cancer, reduce the rate of misdiagnosis.
- HR-HPV detection /
- atypical squamous cell of undetermined significance /
- hybrid capture II

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