Clinical study of curcumin therapy for acute paraquat poisoning
-
摘要: 目的：探讨姜黄素治疗急性百草枯口服中毒的临床疗效。方法：选择2007年3月-2010年3月在院救治的急性百草枯口服中毒患者74例，分为常规治疗组、激素治疗组和姜黄素治疗组。3组均常规对症治疗，激素治疗组在此基础上给予地塞米松25 mg，静脉注射，每日1次。姜黄素治疗组在此基础之上给予姜黄素500 mg/kg，口服，每日1次。在治疗第3天、7天、21天进行疗效评价，并对各组患者所出现的并发症进行统计。常规治疗组、激素治疗组和姜黄素治疗组均根据服毒量分组比较（20%原液或相当量<50 ml组和 ≥ 50 ml组）。结果：中毒治疗第3天，7天，21天，各组相比较，激素治疗组和姜黄素治疗组存活率均明显比常规治疗组高（均P<0.05），而姜黄素治疗组生存率与激素治疗组相比差异无统计学意义（P>0.05）。各组并发症发生率，即肺纤维化、急性肾功能衰竭、肝功能衰竭、MODS、DIC等并发症在激素治疗组和姜黄素治疗组均明显低于常规治疗组（均P<0.05），而激素治疗组与姜黄素治疗组之间比较差异无统计学意义（P>0.05）。结论：对急性百草枯口服中毒患者给予姜黄素治疗，其存活率和严重并发症发生率得到一定程度的改善，初步显示较好的疗效。Abstract: Objective: To investigate the clinical effect of oral curcumin in the treatment of acute paraquat poisoning.Method: There were 74 cases of acute oral paraquat poisoning patients admitted at the First Affiliated Hospital of Dalian Medical University from march 2007 to March 2010,and they were divided into the conventional treatment group, steroid therapy group and the curcumin therapy group. After admission, patients in three groups were given symptomatic treatment. Patients in steroid therapy group were given dexamethasone 25 mg by intravenous injection once a day on the basis of conventional therapy. Patients in Curcumin therapy group were given curcumin 500 mg/kg by oral medication once a day. The efficacy was evaluated after the treatment for 3 days, 7 days and 21 days, and the arising complications were counted in each group for statistical analysis. Patients in all the group were compared according to poison volume group (20% stock solution or the equivalent amount of <50 ml group and ≥ 50 ml group).Result: The survival rate of the steroid therapy group and the curcumin therapy group was significantly higher than that of the conventional treatment group at the treatment of 3, 7 and 21 days (P<0.05). There was no significant difference of the survival rate between the curcumin therapy group and the steroid group (P>0.05).The complication rate in each group including pulmonary fibrosis, acute renal failure, liver failure, MODS, DIC in steroid therapy group and curcumin therapy group were significantly lower than that of the conventional treatment group (P<0.05). There was no significant difference for the complication rate between the steroid therapy group and the curcumin therapy group (P>0.05).Conclusion: Acute paraquat poisoning patients who were treated with oral curcumin therapy can get an improved survival rate and the decreased incidence of serious complications. Curcumin therapy has shown some good effect to some extent.
-
Key words:
- paraquat poisoning /
- curcumin desemedison /
-
-
[1] HUANG C J,YANG M C,UENG S H.Subacute Pulmonary manifestation In a survivor of severe Paraquat intoxication[J].Am J Med Sci,2005,33:254-256.
[2] LEE E Y,HWANG K Y,YANG J O,et al.Predictors of survival after acute Paraquat Poisoning[J].Toxicol Ind Health,2002,18:201-206.
[3] VENKATESAN N.Pulmonary protective effects of curcumin against paraquat toxicity[J].Life Sci,2000,66:21-28.
[4] HOUZE P,BAUD F J,MOUY R,et al.Toxicokinetics of Paraquat in Humans[J].Hum ExP Toxicol,1990,9:5-12.
[5] FUKUSHIMA T,TANAKA K,LIM H,et al.Changes in the fatty acid composition and hydroxyproline content in rat lung in relation to collagen synthesis after paraquat administration[J].J Med Sci,2003,49:33-43.
[6] ADACHI J,TOMITA M,YAMAKAWA S,et al.7-Hydroperoxycholesterol as a marker of oxidative stress in rat kidney induced by paraquat[J].Free Radic Res,2000,33:321-327.
[7] ISHII K,ADACHI J,TOMITA M,et al.Oxysterols as indices of oxidative stress in man after paraquat ingestion[J].Free Radic Res,2002,36:163-166.
[8] MUSTAFA A,GADO A M,AL-SHABANAH O A,et al.Protective effect of aminoguanidine against paraquat-induced oxidative stress in the lung of mice[J].Comp Biochem Physiol C Toxicol Pharmacol,2002,132:391-399.
[9] SATOMI Y,TSUCHIYA W,MIHARA K,et al.Gene expression analysis of the lung following paraquat administration in rats using DNA microarray[J].J Toxicol Sci,2004,29:91-100.
[10] KOJIMA S,MIYAZAKY Y,HONDA T,et al.Protective effects of dextran sulfate and polyvinyl sulfate against acute toxicity of paraquat in mice[J].Toxicology,1991,69:93-99.
[11] 陈惜遂,刘元生,郭光华,等.血浆置换术成功救治百草枯中毒的护理技术分析[J].山西护理杂志,1999,13(4):172-173.
[12] AGARWAL R,SRINIVAS R,AGGARWAL A N,et al.Experience with paraquat poisoning in a respiratory intensive care unit in North India[J].Singapore MedJ,2006,47:1033-1037.
[13] AGARWAL R,SRINIVAS R,AGGARWAL A N,et al.Immunosuppressive therapy in lung injury due to paraquat poisoning:a meta-analysis[J].Singapore Med J,2007,48:1000-1005.
[14] LIN J L,LIN-TAN D T,CHEN K H,et al.Repeated pulse of methylprednisolone and cyclophosphamide with continuous dexamethasone therapy for patients with severe paraquat poisoning[J].Crit Care Med,2006,34:368-373.
[15] NAKAMURA T,USHIYAMA C,SHIMADA N,et al.Changes in concentrations of type IV collagen and tissue inhibitor of metalloproteinase-1 in patients with paraquat poisoning[J].J Appl Toxicol,2001,21:445-44.
-
计量
- 文章访问数: 143
- PDF下载数: 78
- 施引文献: 0
下载: